Read Principles of Animal Extrapolation (Environmental Science & Technology: A Wiley-Interscience Series of Texts and Monographs)

Principles of Animal Extrapolation (Environmental Science & Technology: A Wiley-Interscience Series of Texts and Monographs)

Edward J. Calabnese

4.9/5 (19657 ratings)

Description:Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Principles of Animal Extrapolation (Environmental Science & Technology: A Wiley-Interscience Series of Texts and Monographs). To get started finding Principles of Animal Extrapolation (Environmental Science & Technology: A Wiley-Interscience Series of Texts and Monographs), you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.

Pages: —

Format: PDF, EPUB & Kindle Edition

Publisher: —

Release: —

ISBN: 0471087629

Description: Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Principles of Animal Extrapolation (Environmental Science & Technology: A Wiley-Interscience Series of Texts and Monographs). To get started finding Principles of Animal Extrapolation (Environmental Science & Technology: A Wiley-Interscience Series of Texts and Monographs), you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.

Special Offer | $0.00

Special Offer! | $0.00

Principles of Animal Extrapolation (Environmental Science & Technology: A Wiley-Interscience Series of Texts and Monographs)

Principles of Animal Extrapolation (Environmental Science & Technology: A Wiley-Interscience Series of Texts and Monographs)

More Books

Soils Contaminated by Petroleum: Environmental and Public Health Effects

Soils Contaminated by Petroleum: Environmental and Public Health Effects

Performing Ecological Risk Assessments (National Toxicology Program's Chemical Database) 1st edition by Calabrese, Edward J., Baldwin, Linda A. (1993) Hardcover

Performing Ecological Risk Assessments (National Toxicology Program's Chemical Database) 1st edition by Calabrese, Edward J., Baldwin, Linda A. (1993) Hardcover

Air Toxics and Risk Assessment (Toxicology and Environmental Health Series) 1st edition by Calabrese, Edward J., Kenyon, Elaina (1991) Hardcover

Air Toxics and Risk Assessment (Toxicology and Environmental Health Series) 1st edition by Calabrese, Edward J., Kenyon, Elaina (1991) Hardcover